Not a single tumor type was found for which expression of any HH gene was associated with morbidity (H.R. > 1, red color) without a parallel pejorative prognostic value for at least one TGFB gene and either GLI1, or GLI2. Also, for each occurrence when high GLI1 or GLI2 expression was of bad prognosis, the same held true for at least one of the TGFB genes. The gene discussed is GLI1; the disease is neoplasm.