FOSB and drug-induced dyskinesia: To further validate our LID model we measured two biochemical markers of l-DOPA induced dyskinesia, expression of FosB and phosphorylation of histone 3 on Ser-10 (pS10-H3)54–56, and found that both markers were elevated in the lesioned striatum relative to the intact side after l-DOPA priming and SKF 81297 challenge (Supplementary Fig. S9).