For the Ubiquitin carboxyl-terminal hydrolase 46 (USP46) that plays a role in neurotransmission, histone deubiquitination and tumor suppression47, the most frequent transcript in cancer cells was ENST00000451218 with 137 occurrences, which lacked the second exon of the GTEx transcript ENST00000441222. This evidence concerns the gene USP46 and cancer.