AVP and diabetes insipidus: We again found that complete deletion of Bmal1 required that the AVP-ires-Cre mice be in the homozygous state (i.e., AVPcre/cre); unfortunately, this also produced profound diabetes insipidus in these mice, likely secondary to disruption of AVP function (allele itself or Bmal1) in the supraoptic hypothalamus.