FGF21 and Insulin resistance: FGF21 decreases insulin resistance, enhances fat oxidation, and suppresses hepatic steatosis in the liver of DIO and ob/ob mice,553,554 which is related to the increased level of adiponectin in vivo.556 FGF21 participates in high-fat, low-carbohydrate ketogenic diet-induced triglyceride clearance, hepatic lipid oxidation, and ketogenesis.