FGFR3 and chondrodysplasia: In ACH mice, subcutaneous injection of sFGFR3, to compete with endogenous FGFR3 ligands, showed a dose-dependent rescue of chondrodysplasia phenotypes.735 Besides, in TD II model, administration of peptide P3 with the ability to downregulate the activity of FGFR3 rescues the lethal phenotype and partially restores the structural distortion of growth plates.736