FGFR1 and breast cancer: In osteoprogenitor cells, nuclear FGFR2-mediated regulation of rDNA transcription promotes self-renewal over terminal osteoblast differentiation.95,96 In invading breast cancer cells, FGFR1 undergoes nuclear translocation and activates the transcription of genes critical for cell migration.94 The activating mutant FGFR2 Y376C in endometrial cancer has increased perinuclear localization and appears to be involved in disrupting cell polarity in metastatic cells.99 In pancreatic cancer, nuclear FGFR3 correlates with metastatic disease and poor overall prognosis.90