Many tumor cell lines produce FGF2.467 Inhibition of FGFR1 by FGF2 antisense complementary DNAs (cDNAs) suppressed vascularization and growth of human melanomas in nude mice.468 Furthermore, FGF levels were correlated with intratumoral MVD, an important parameter for tumor progression.469 In some tumors like melanoma, FGF2 level has a strong correlation with MVD and clinical outcome of the patients.469 However, whether FGFs/FGFRs also influence tumor parenchyma needs to be further clarified. This evidence concerns the gene FGF2 and melanoma.