FGF23 promotes sodium reabsorption by increasing the sodium chloride co-transporter expression in the distal renal tubules resulting in volume expansion and hypertension.587 FGF23 directly promotes calcium reabsorption in the kidney by regulating transient receptor potential vanilloid-5 channels in the distal renal tubules.588 Furthermore, 1,25(OH)2D3 promotes calcium absorption in the small intestine.589 PTH promotes calcium absorption in the kidney via increasing the 1,25(OH)2D3 level and accelerates calcium release from the bone by stimulating bone resorption. The gene discussed is FGF23; the disease is Hypertension.