FGFR1 and breast cancer: N-cadherin is associated with FGFRs through their acidic box-mediated activation of FGFRs and their downstream signaling in numerous cells.45 In breast cancer cells, formation of N-cadherin complexes with FGFR1 can decrease the internalization and lysosomal degradation of FGFR1, and thus sustain the receptor signaling via MAPKs, whereas silencing of N-cadherin results in the accelerated FGFR1 degradation.