FGF19 transgenic mice show decreased expression of lipogenic enzymes and liver triglyceride levels.530 FGF19 inhibits the expression of lipogenic enzymes and the insulin lipogenic action in rat primary hepatocytes through activating STAT3 signaling and repressing PGC-1β expression,543 and also enhances the expression of fatty acid oxidation-related proteins.544 Long-term treatment by FGF19 reduces liver lipid accumulation in vivo and protects liver from diet-induced steatosis.545. This evidence concerns the gene FGF19 and steatosis.