It was shown that intracoronary FGF2 administration preserved myocardial function by increasing vascularization.478 Some clinical trials demonstrated that FGF2 administration can improve the symptoms of patients with coronary artery disease or peripheral artery disease.448,479 In addition, inhibition of FGF2/FGFR1 by antisense cDNAs blocked intratumoral angiogenesis and arrested the growth of human melanomas grown subcutaneously in nude mice.468. This evidence concerns the gene FGF2 and melanoma.