FGF ligands and receptors promote angiogenesis in a variety of tumors.672 Wang and Becker673 showed that delivery of an episomal vector containing antisense FGF2 or FGFR1 cDNA could completely prevent the growth of tumors partially through the blockage of angiogenesis in the human melanoma grown as a subcutaneous tumor model in nude mice. Here, FGFR1 is linked to neoplasm.