FGFR2 and bent bone dysplasia syndrome 1: FGFR2 mutations (FGFR2M391R and FGFR2Y381D) located in the TMD can reduce plasma membrane levels of FGFR2, and amplify its nuclear and nucleolar presence in growth plate chondrocytes derived from patients with skeletal disorder bent bone dysplasia syndrome (BBDS).95,96 Interestingly, posttranslational modifications, such as glycosylation, also contribute to the nuclear localization of FGFRs.