It was further reported that FGF23 prevented leukocyte recruitment and impaired host defense in CKD.374 FGF23-α-Klotho-FGFR2 axis plays a central role in this process by activating PKA and inhibiting Rap1 that will finally inactivate β2-integrin function.374 FGF23 could also facilitate the rolling of neutrophils.374. This evidence concerns the gene FGF23 and chronic kidney disease.