However, exogenic FGF2 could attenuate inflammatory response such as the decreased expression of IL-1β in epileptogenesis-associated neuroinflammation.501 In addition, inhaling recombinant FGF2 decreases lung inflammation in asthma and COPD.502,503 Thus, targeting FGF2 is a potential method to alleviate certain inflammatory diseases such as neuroinflammation, asthma, and COPD. This evidence concerns the gene FGF2 and chronic obstructive pulmonary disease.