FGF3 and Acute otitis media: The level of FGF3 in sinonasal tissues is significantly upregulated in acute allergic rhinitis and chronic sinonasal inflammation mouse models.504,505 However, FGF3 level in middle ears is significantly downregulated in mouse model for acute otitis media.506 Combining these results, we speculate that the role of FGF3 in inflammation may be distinct in the different tissues/organs.