Most of these TFs (13 of 19) had known immunological roles according to previous studies (Figure 6E and Supplemental Table 13), including 10 master TFs (RREB1, RARA, HIC1, RARG, EGR3, ETS1, SP1, PAX5, MZF1, and CTCF) (56) in blood cell types, indicating their potential central regulatory roles for autoimmune diseases. This evidence concerns the gene CTCF and autoimmune disease.