TSC1 and neurodevelopmental disorder: Hyperactivation of mTORC1 activity is also found in the neurodevelopmental disorder tuberous sclerosis complex (TSC) (11), resulting from mutations in either the gene for hamartin (TSC1) or tuberin (TSC2), causing the development of tumors and manifesting in epilepsy, cognitive disability, and neurobehavioral abnormalities (12).