We also demonstrated that the severity of Kagami-Ogata syndrome exhibits good correlation with the degree of RTL1 overexpression but does not have any apparent correlation with the expression levels of DLK1, MIRG or other miRNA clusters (Kagami et al., 2008). The gene discussed is DLK1; the disease is multiple congenital anomalies due to 14q32.2 maternally expressed gene defect.