MAPK8 and neoplasm: Moreover, the JNK pathway is the main regulator of matrix metalloproteases (MMPs) expression and cell motility in many organisms and tissues including tumours like GB (Cheng et al., 2012; Ispanovic and Haas, 2006; Lee et al., 2009; Portela et al., 2019; Uhlirova and Bohmann, 2006; Zeigler et al., 1999).