EGFR and astrocytoma (excluding glioblastoma): The causes of GB are under debate (McGuire, 2016), 5% of the patients develop GB after a low grade astrocytoma (Alifieris and Trafalis, 2015) and the most frequent mutations include gain of function of the epidermal growth factor receptor (EGFR) (97%) and the phosphatidylinositol-3 kinase (PI3K)/phosphatase and tensin homologue (PTEN) pathways (88%) (Hayden, 2010).