To deeply validate the function of LINC00301-PRC2 interaction, RNA pull-down assays using streptavidin-conjugated beads were conducted to verify that biotinylated LINC00301 binds with EZH2 but not with SUZ12 in NSCLC cells (Fig. 6i, j, Additional file 1: Figs. S5E and S5F). Here, LINC00301 is linked to non-small cell lung carcinoma.