PTK6 and breast carcinoma: LINK-A promotes HIF1α phosphorylation at tyrosine 565 and tryptophan 797 loci by regulating BRK and LRRK2; this process leads to the activation of HIF1α signals under normoxia conditions in triple-negative breast cancer (TNBC), resulting in glycolysis restructuring and breast cancer tumorigenesis [26].