The results demonstrated that LINC00301 KD repressed Treg but facilitated CD8+ T cell infiltration while LINC00301 OE accumulated Treg but suppressed CD8+ T cell infiltration in LA-4/KLN-205 burdened tumors in C57BL/6 J mice (Fig. 4c–f), suggesting LINC00301 exerts an immune-suppressive role in NSCLC by recruiting Treg cells. This evidence concerns the gene CD8A and non-small cell lung carcinoma.