AGAP2-AS1 mediates H3K27me3 at LATS2 and KLF2 gene promoters by specifically combining with LSD1 and EZH2 to inhibit LATS2 and KLF2 expression levels and promote cell proliferation and migration/invasion but suppress cell apoptosis in NSCLC [50]. This evidence concerns the gene LATS2 and non-small cell lung carcinoma.