Interestingly, extracellular vesicles (EVs) containing annexin A6/LDL receptor-related protein 1/thrombospondin 1 (ANXA6/LRP1/TSP1) are solely present in the serum from PaCa patients. The gene discussed is ANXA6; the disease is permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.