Continual infusion of the vasoactive peptide angiotensin II, associated in the previous experiments with vascular remodeling and atherosclerosis, lead to the development of aneurysms in the suprarenal abdominal aorta in apolipoprotein E knock out (ApoE-/-) mice without affecting the thoracic aorta [37]. This evidence concerns the gene APOE and aneurysm.