DNMT1 and breast carcinoma: EGCG (40 μM) treatment of MCF7 and MDA-MB-231 breast cancer cell lines for 3, 6, 9, and 12 days displayed a decrease in cell proliferation and increase in apoptosis; this was thought to occur via hTERT promoter hypomethylation and inhibition and was the consequence of a decrease in DNMT activity [206].