TP53 and hepatocellular carcinoma: Hypomethylation in the promoter region of the oncogene c-myc was found in hepatocellular carcinoma tissue of choline-deficient rats, whereas the promoters of some tumor suppressor genes (p53, p16INK4a, PtprO, Cdh1, and Cx26) were hypermethylated [94,95,96].