DNMT3B and cervical carcinoma: In human cervical cancer (HELA) cell line, SFN (2.5 μM) caused cell cycle arrest and apoptosis by decreasing the expression and enzymatic activity of DNMT3B, which led to promoter hypomethylation and the upregulation of tumor suppressor genes (RARβ, CDH1, DAPK1, and GSTP1) and pro-apoptotic proteins (Bax) [13].