BRCA1 and breast carcinoma: In breast cancer (MCF7 and MDA-MB-231) cells, curcumin (10–20 μM; 72 h) was shown to decrease cell proliferation by inducing a promoter DNA hypomethylation-mediated reactivation of the breast cancer 1 (BRCA1) tumor suppressor and DNA repair gene and the RASSF1A tumor suppressor gene, whilst inducing promoter DNA hypermethylation and suppressing the expression of the proto-oncogene gamma-synuclein (SNCG) [14,126].