In adults, a mean age of 57.8 years and belonging to the ethnic groups of White, African American, or Hispanic, who had previous cases of colorectal adenomas, the use of 1 mg/day of folic acid increased the methylation of the CpG loci of the proto-oncogenes estrogen receptor alpha (ERα) and secreted frizzled-related protein 1 (SFRP1) [56]. The gene discussed is ESR1; the disease is colorectal adenoma.