Resveratrol (15 μM) was shown to decrease the enzymatic activity and mRNA expression levels of DNMT1, DNMT3A, and DNMT3B in MDA-MB-157 and HCC1806 breast cancer cell lines, which led to a significant decrease in 5-methylcytosine levels and an overall reduction in global DNA methylation patterns [151,153]. The gene discussed is DNMT3B; the disease is breast cancer.