Genistein (2–20 μmol/L) inhibited the proliferation of human esophageal squamous cell carcinoma (KYSE 510) cell line by reversing DNA hypermethylation and reactivating the expression of RARβ, p16INK4a, and MGMT. This reversal of RARβ promoter hypermethylation and increase in its expression was also observed by genistein in KYSE 150 cell line and prostate cancer (LNCaP and PC3) cell lines [15]. Here, CDKN2A is linked to prostate cancer.