Genistein also induced promoter hypomethylation and reactivated the expression of tumor suppressor genes GSTP1, EPHB2, p21, RARβ, p16INK4a, and MGMT in breast cancer, kidney cancer, esophageal squamous cell carcinoma, and prostate cancer cell lines, leading to cell cycle arrest and cell death [15,183,184,185]. Here, CDKN2A is linked to esophageal squamous cell carcinoma.