In one study, the treatment of prostate cancer (PC3 and DU145) cell lines with curcumin (5.0 μM) and quercetin (5.0 μM) for 48 h enhanced the decrease in cell proliferation and apoptosis by inhibiting DNMT activity and inducing global DNA hypomethylation as well as androgen receptor (AR) promoter hypomethylation and reactivation [207]. Here, AR is linked to Familial prostate cancer.