DNMT3B and breast cancer: In contrast, resveratrol (15 μM) treatment for 9 days increased DNMT3B activity that led to the hypermethylation and silencing of the MAML2 (mastermind-like protein 2; co-activator of the oncogenic NOTCH signaling pathway) gene in MCF10CA1h and MCF10CA1a human breast cancer cell lines [156].