APC and colorectal cancer: Additionally, in C57BL/6 mice, maternal and post-weaning folate-deficient (0.4 mg/kg diet) diets were shown to modulate colorectal cancer development by inducing p53 promoter hypomethylation in adults and adenomatous polyposis coli (APC) promoter hypermethylation in APC+/min offspring, respectively [55].