WNT5A and malignant colon neoplasm: Contrastingly, in Sprague–Dawley rats, genistein (140 mg/kg) was found to decrease cell proliferation and induce the apoptosis of colon cancer cells through promoter hypermethylation and inactivation of the Wnt signaling activators, Sfrp2, Sfrp5, and Wnt5a [180].