EGCG-mediated inhibition of DNMTs has been linked with promoter demethylation and the re-expression of several tumor suppressor genes such as p21, p16INK4a, RARβ, MGMT, and human mutL homologue 1 (hMLH1) in various cancer cell lines [193,194,198,199]. This evidence concerns the gene CDKN2A and cancer.