Enhanced HDAC5 expression was observed in the hippocampus of young adult and middle-aged MS animals compared to their age-matched controls (young adulthood: 1.00 ± 0.13 vs. 1.43 ± 0.12, t = 2.979, p = 0.007; middle adulthood: 1.00 ± 0.06 vs. 1.80 ± 0.07, t = 8.466, p = 0.003, Figure 4B). Here, HDAC5 is linked to myeloid sarcoma.