PDGFRA and congenital bilateral aplasia of vas deferens from CFTR mutation: Bearing in mind that CAVD is an age-related pathology affecting mostly older subjects, the decreased percentage and number of CD34+/PDGFRα+ VICs in elder individuals as well as in valves subjected to initial calcification suggests that this VICs subpopulation is only indirectly involved in calcific degeneration.