HCV infection elicites changes in the proteome of host cells that resembled the Warburg effect described in cancer cells toward lactate production and the support of continuous glycolysis; concurrently, the up-regulation of citrate synthase (CS) and other lipogenic enzymes 24 h after infection was interpreted by the authors of the latter study as indicative of re-routing of the tricarboxylic acid (TCA) cycle for cytosolic accumulation of citrate, which would be used in FA synthesis. Here, CS is linked to infection.