In a similar study, whole exome sequencing in 32 PCa patients revealed serine/arginine repetitive matrix 4 (SRRM4) splicing factor as a master regulator of >66% of downstream events that drive neurogenesis, through targeting RE1 silencing transcription factor (REST) and enhancing loss of function of TP53 [22]. The gene discussed is TP53; the disease is posterior cortical atrophy.