Additional molecular analysis revealed that, regardless of the above seven subclasses, 25% of the prostate cancers harbored mutations in genes involved in kinase signaling pathways, such as PI3K or mitogen-activated protein kinase (MAPK) pathways, and 19% of the PCa tumors harbored inactivating mutations in DNA repair genes [13]. This evidence concerns the gene PIK3CA and posterior cortical atrophy.