An interesting genetic overlap has been described between ACM and catecholaminergic polymorphic ventricular tachycardia (CPVT) caused by a mutation in RYR2; however, the role of RYR2 in ACM must still be clarified because of the high background rate of rare missense RYR2 variants [80]. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.