Mutations in genes encoding Ca2+ channels or regulators of Ca2+ homeostasis have been shown to cause inherited arrhythmogenic diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT), Brugada syndrome, Timothy syndrome, and long and short QT syndromes [56,59,105]. The gene discussed is CA2; the disease is catecholaminergic polymorphic ventricular tachycardia.