IL6 and melanoma: Huber et al. [69] found that a special set of miRNA (miRNA-146a, -155, -125b, -100, -125a, -146b, -99b and let-7e) is responsible for HLA-DR downregulation, secretion of IL-6 and CCL2 by monocytes upon the exposure to melanoma EV, leading to the inhibition of T cell effector functions.