Macrophages are recruited at TME, in response to the secretion by tumor cells and other TME cell types, of a number of chemoattractant soluble factors, including vascular-endothelial growth factor A (VEGF-A) [44], chemokine ligand 2 (CCL2) [45], and colony-stimulating factor 1 (CSF-1) [46]. The gene discussed is VEGFA; the disease is neoplasm.