NR3C2 and neoplasm: In addition, a very recent report showed that direct binding of MR with a synthetic peptide (RP-182), i.e., an analogue of naturally occurring antimicrobial peptides, activates phagocytosis and autophagy in M2-like macrophages, reverting these cells into an anti-tumor M1-like phenotype with increased M1 cytokine production and phagocytosis of cancer cells [103].