However, in our RNAseq analysis, other genes previously associated with OA such as SOX4, HIF-2α, or VEGF, are down-regulated following LSD1 inhibition, suggesting that this enzyme exerts a control of the cartilage integrity beyond the regulation of COL9A1. The in vivo investigation of its role toward osteoarthritis progression would thus be of great interest. This evidence concerns the gene EPAS1 and osteoarthritis.