CRP and mood disorder: Just as is seen in the sera of patients following toxin or microbial invasion, exposure to acute or repeated life stressors (dealing with chronic illness, job loss, divorce, death of spouse, threat, isolation, rejection, as well as engaging in very strenuous physical exercises) increases the same inflammatory markers, viz, C-reactive protein (CRP), interleukins (IL-1, IL-6, IL-18, etc.), soluble tumor necrosis factor-α receptor (TNF-α), and NFκB mRNA (inflammatory proteins transcription factor) in leukocytes, which cause mood disorders [41,42,43,44,45,46].