Inflammation in the central nervous system (CNS) affects brain functions as well as moods, from mania to severe MD, and MD or MS sufferers for example, show elevated concentrations of inflammatory molecules (IL-1β, IL-2, IL-6, IL-18, TNF-α, nitric oxide, IFN-γ, etc.)in sera and CSF. The gene discussed is IL1B; the disease is myeloid sarcoma.