Moreover, investigation of additional somatic variants in JAK2, in other myeloproliferative associated genes such as MPL or in genes involved in the age and clonal hematopoiesis that have been associated with an increased risk of cardiovascular disease, particularly in DNMT3A, TET2, and ASXL1, could have provided more valuable data [45]. This evidence concerns the gene DNMT3A and cardiovascular disorder.