TNFAIP3 and inflammation: Recent investigations support an anti-inflammatory role of TNFAIP3, indeed, knockout mice for this gene evolve multiple organ inflammation [115], TNFAIP3 gene silencing in dendritic cells leads to the release of specific co-stimulatory factors, such as pro-inflammatory cytokines [116] and genetically TNFAIP3 deficient mice also show severe intestinal inflammation [115].