Moreover, in the AD mouse model 5XFAD, constitutively active Rheb resulted in increased levels of neurotrophic molecules such as BDNF and ciliary neurotrophic factor (CNTF), and their respective receptors tropomyosin receptor kinase B (TrkB) and CNTF receptor α subunit (CNTFRα) [69]. Here, CNTF is linked to Alzheimer disease.