MAPT and neurodegenerative disease: Hence, depending on which protein is accumulated, neurodegenerative diseases can be classified in different groups: amyloidosis diseases, Tau protein impairments, and α-synucleinopathies that are characterized by the accumulation and aggregation of β-amyloid (Aβ) peptides, Tau protein impairments, and α-Synuclein (α-syn) accumulation, respectively [11].