ALDH6A1 and posterior cortical atrophy: Among the proteins mapped to oxidative phosphorylation in our network, ALDH6A1, an enzyme catalysing the oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA, was found to be overexpressed in PCa tissues in comparison to normal prostatic tissue and was also significantly associated with lymphatic invasion in PCa [53].