Interestingly, our results indicate a role for MCs in driving the increase of TSLP and IL-33 but, at the same time suggesting that these cytokines are not drivers of the scored clinical AD-like symptoms, since the c-kit dependent MC-deficient Wsh−/− mice had lower levels of TSLP and IL-33 but higher clinical scoring. This evidence concerns the gene IL33 and Alzheimer disease.