However, the importance of IL-33 and ST2 was recently challenged in a high dose MC903-induced (4 nmol) AD model in C57BL/6J Taconic mice, where even the double knockout deleting both IL-33 and ST2 showed similar development of ear thickness, leukocyte infiltration and transcription of IL-4 and IL-13, as the WT mice [46]. This evidence concerns the gene IL4 and Alzheimer disease.