Interestingly, following the comparison of circRNA expression profiles among CRC cell lines with distinct KRAS mutational status, Dou et al. demonstrated that circRNA expression levels in KRAS-mutated cells are significantly lower than in the KRAS-wild type cells, while they showed that circRNAs can be transferred to exosomes, where they are abundant [45]. This evidence concerns the gene KRAS and colorectal carcinoma.