A recent study investigated circRNAs in serum exosomes of CRC patients and concluded that exosomal circ_0004771 (gene origin: NRIP1) is upregulated in the serum of CRC patients, compared to healthy controls; however, the levels of this circRNA were lower in CRC cell lines and tissues, compared to normal colorectal mucosa [102]. This evidence concerns the gene NRIP1 and colorectal carcinoma.