CD4 and neoplasm: In the context of immune cells, a decreased expression of human leukocyte antigen (HLA) class-I molecules and consequently failure of Ag presentation by APCs [30], an impaired tumor antigen processing [31], an increase in Tregs [32], invariant natural killer T cells (iNKT) [33], CD14+HLA-DR−/low, monocytic-like myeloid-derived suppressor cells (MDSC) [34], tumor-associated macrophages (TAMs) [35], as well as a reduced CD4+ T helper cells have been reported [36].