Among them programmed death-1 (PD-1), cytotoxic T-lymphocyte antigen 4 (CTLA-4), T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) and Lymphocyte-activation gene 3 (LAG-3) have been studied in chronic hepatitis and HCC. This evidence concerns the gene LAG3 and hepatocellular carcinoma.