In the context of PD-1/PD-L1 pathway, a high expression levels of PD-1/PD-L1 as well as of markers of inflammatory response on HCC immune cells infiltrates has been demonstrated [43]; furthermore, an increase in tumor infiltrating and circulating PD-1+CD8+ T cells has been associated with disease progression after curative hepatic resection [47]. This evidence concerns the gene CD8A and neoplasm.