Melanomas present the highest alteration rate with over 90% of BRAFV600E mutations, accompanied with 30–40% mutations in PTEN. Autophagy is essential for survival of cells with BRAFV600E mutations [48,99,100], maintenance of lung cancer cell metabolic homeostasis [101,102] and development of treatment resistance in colorectal cancer cells [103]. This evidence concerns the gene PTEN and melanoma.