EGCG also acts through different mechanisms in order to arrest cell cycle and induce apoptosis, in fact in 12-week-old TRAMP mice, contrary to 28-week-old mice, it suppressed PCa development at an early stage after oral intake of EGCG by regulating IGF-1-related signaling and COX-2 levels [134]. Here, PTGS2 is linked to posterior cortical atrophy.