TG and cancer: Nevertheless, proteins whose tryptic fragments were most frequently attributed to MSI components markedly upregulated in all types of tumor ROIs (compared to normal thyroid) included thyroglobulin, heat shock proteins, and proteins associated with several gene ontology (GO) terms involved in cancer development: response to growth factors, cytoskeleton organization, extracellular matrix organization, cell-cell adhesion, cell motility, glycolysis and glucose metabolism, regulation of immune response, and inflammatory response (Supplementary Table S9).