HNRNPUL2 and adenoma: On the other hand, very few components specifically distinguished benign adenoma: when compared to normal thyroid all components upregulated in FA were also upregulated in malignant cancers, while only two components (m/z 1183.6 and 1184.6) markedly upregulated in cancer (large or very large effect size) were not upregulated in FA (small effect size) (components putatively corresponded to a fragment of ribonucleoprotein HNRNPUL2).