Knockdown of miR-27a in CRC cells increased the levels of citrate synthase activity (TCA cycle gatekeeper enzyme), dihydrolipoamide s-acetyltransferase (DLAT, the E2 component of PDH), intracellular ATP and ROS, which implicates the activation of mitochondrial respiration [31]. This evidence concerns the gene DLAT and colorectal carcinoma.