The Rosenberg and Patterson criteria included eight major (asthma, transient pulmonary infiltrates, immediate cutaneous reactivity to A. fumigatus, elevated total serum IgE, precipitating antibodies against A. fumigatus, peripheral blood eosinophilia, elevated serum IgE and IgG to A. fumigatus, central/proximal bronchiectasis with normal tapering of distal bronchi) and three minor criteria (expectoration of golden-brownish sputum plugs, positive sputum culture for Aspergillus species, late skin reactivity to A. fumigatus), as shown in Table 2. The gene discussed is IGHE; the disease is asthma.