Furthermore, LIM activates the ERM proteins radixin (RDX), ezrin (EZR), and moesin (MSN) (Figure 4, fourth panel), which are important regulators of microvilli formation, cell adhesion, and membrane ruffling (reviewed by Tsukita et al. [100]) and potential drivers of cancer progression (reviewed by Clucas et al. [101]). This evidence concerns the gene EZR and cancer.