In this study, we developed a MIPs-NGS and TSCA-NGS targeted re-sequencing panels for nine sodium channel genes (SCN3A, SCN8A-SCN11A, and SCN1B-SCN4B) known to be associated with neuropathic pain [19, 27], and compared their sensitivity, specificity, targeting efficiency, performance and cost effectiveness. The gene discussed is SCN11A; the disease is neuropathic pain.