While acetylcholine esterase and beta-secretase 1 are highly druggable and drugged, it is interesting to note that APOE, one of the main risk factors for Alzheimer’s disease [23], does not score well in the druggability and chemistry area, which is consistent with the poor druggability of an apolipoprotein. This evidence concerns the gene BACE1 and early-onset autosomal dominant Alzheimer disease.