In contrast, in the HEV gt3 infection, metal ion binding, oxidation-reduction process, and protein glycosylation DEGs were involved in the early phase, negative regulation of viral genome replication, defense response to virus and immune response at the peak, and T cell cytokine production, endothelial cell migration, and negative regulation of the ERK1 and ERK2 cascade process were significantly enriched in the decline phase of infection (Fig 4B). The gene discussed is MAPK3; the disease is infection.