MAPK1 and infection: In contrast, in the HEV gt3 infection, metal ion binding, oxidation-reduction process, and protein glycosylation DEGs were involved in the early phase, negative regulation of viral genome replication, defense response to virus and immune response at the peak, and T cell cytokine production, endothelial cell migration, and negative regulation of the ERK1 and ERK2 cascade process were significantly enriched in the decline phase of infection (Fig 4B).