A review by Bourgonje et al.25 also points out that it is the relative proportion of ACE to ACE2 receptors that is responsible for the resultant pro-inflammatory and pro-fibrotic symptomatology, and it has been reported that these may be affected by gender, with males having a relatively higher proportion of ACE to ACE2, thus favoring inflammation and colitis. Here, ACE2 is linked to colitis.