F9 and hemoglobin measurement: In the F9 gene, c.1294G>A(p.Gly432Ser) was classified as likely pathogenic and has been recorded in HB patients from India, South Korea, Germany, and the United States (Johnsen et al., 2017; Kwon, Yoo, Kim, & Kim, 2008; Miller et al., 2012; Wulff, Schröder, Wehnert, & Herrmann, 1995).