It is suggested that HGF may promote the immune escape of tumor cells through overexpression of PD‐L1 in EGFR‐TKI‐resistant NSCLC cells; HGF also induces PD‐L1 expression in NSCLC cells by activating PI3K/AKT, MAPK, and AP‐1. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.