It was found that HGF induced the expression of PD‐L1 in EGFR‐mutated NSCLC cells and regulated the proliferation and cytotoxicity of T lymphocytes: HGF not only activates the c‐MET signaling pathway in lung adenocarcinoma and induces drug resistance in EGFR‐TKIS151, 152 but also promotes the transcription of endogenous c‐MET genes.153. Here, CD274 is linked to non-small cell lung carcinoma.