Mir‐8 transcriptional inhibition dissolves the inhibition of miRNA on the expression of PD‐L1 in tumor cells, leading to the failure of CD8 + T cells. Downregulation of mir‐8 family may be related to the resistance of PD‐1/PD‐L1 monoclonal antibody. The gene discussed is PDCD1; the disease is neoplasm.