However, in RCC (Renal cell carcinoma) tumor cells resistant to PD‐1 monoclonal antibody, metabolic changes that meet the energy demand for rapid cell proliferation are shown, such as significantly upregulated levels of hypoxia adaptation factors, glucosaldehyde acidification, and overexpression of nutrient transportation‐related molecules. This evidence concerns the gene PDCD1 and hereditary clear cell renal cell carcinoma.