Magnesium has been shown to effectively prevent mineralization in multiple experimental models of vascular calcification, including cultured VSMCs (Kircelli et al, 2012; Louvet et al, 2013; Bai et al, 2015; Ter Braake et al, 2018), uremic rats (Diaz‐Tocados et al, 2017), and mouse models of pseudoxanthoma elasticum (PXE; Abcc6‐null mice) (Gorgels et al, 2010) and generalized arterial calcification of infancy (GACI; Enpp1‐null mice) (Kingman et al, 2017). This evidence concerns the gene ENPP1 and Pseudoxanthoma elasticum.