CASC8 and esophageal squamous cell carcinoma: However, when the CASC8 rs1562430 AA homozygous genotype was used as the reference group, the GG genotype was significantly associated with increased risk of ESCC (GG vs. AA: adjusted OR = 2.05, 95% CI: 1.18–3.55, P = 0.010), whereas the AG genotype was not associated with ESCC risk (AG vs. AA: adjusted OR = 0.91, 95% CI: 0.75–1.09, P = 0.304).