CASC8 and esophageal squamous cell carcinoma: In a recessive model using CASC8 rs1562430 AA/GG genotypes as the reference group, the GG homozygous genotype (GG vs. AA/GG: adjusted OR = 2.11, 95% CI: 1.22–3.64, P = 0.007) was significantly associated with increased risk of ESCC, whereas the AG/GG homozygous genotype (AG/GG vs. AA/GG: adjusted OR = 0.97, 95% CI: 0.81–1.16, P = 0.725) was not associated with ESCC risk.