In our study, by integrating multiple gene expression datasets generated by different techniques, i.e. microarray and NGS, and conducting meta-analysis and RNA-seq analysis, we identified four important DEGs, namely, IGFBP2, PTPRN, STEAP2 and SLC39A10 in primary GBM which were also significantly associated to OS. This evidence concerns the gene IGFBP2 and glioblastoma.