Finally, adopting a therapeutic perspective, there is the promise [based on work in typical amnestic Alzheimer’s disease (Hardy et al., 2017, 2018)] that residual auditory plasticity might be harnessed in PCA to benefit hearing under challenging listening conditions, via cognitive training and pharmacological modulation with acetylcholinesterase inhibitors. The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.