Several studies have shown that CXCR4 can promote mast cell chemotaxis to inflammatory sites (Limón-Flores et al., 2009; Lv et al., 2019; Patadia et al., 2010), and IFRD1 may involve in neutrophilic inflammation in cystic fibrosis (Blanchard et al., 2011; Gu et al., 2009; Hector et al., 2013). This evidence concerns the gene IFRD1 and cystic fibrosis.