Female NAFLD subjects’ serum ApoA1 level is much higher than Male’s (1.62 vs 1.42, P < 0.05), which is exactly consistent with the results from other populations.The difference in ApoA1 level in different gender groups implied that sex hormones may play an important role in serum ApoA1 level. The gene discussed is APOA1; the disease is metabolic dysfunction-associated steatotic liver disease.