Consistent with METHY analysis, a pan-gastrointestinal carcinoma cluster with COAD/READ-STAD was gathered in C2, which had high level of CDH1, CLDN7 and TYRO3, and a low level of CAV1 (Burgermeister et al., 2007; Di Bartolomeo et al., 2016; Qin & Qian, 2018). The gene discussed is CLDN7; the disease is digestive system carcinoma.