A key factor that regulates this intratumoral microvessel density is the vascular endothelial growth factor and some other genes, P53 mutation have also been found to be associated with high microvessel density because it increases the expression of factors that stimulate angiogenesis, decreases the factors that inhibit angiogenesis, and stimulates tumor cell proliferation [27,28]. This evidence concerns the gene VEGFA and neoplasm.