Tumors in the left side of the colon and the rectum tend to have an earlier presentation than right sided tumors and show less aggressive behavior than right side colonic cancers, this is proved by many studies that included a large number of colorectal patients, although in our patients there was stronger expression of both P53 and MVD in left side colorectal tumors when compared to the right side tumors. Here, TP53 is linked to colonic neoplasm.