TP53 and neoplasm: The size of the tumor has not been found to have a direct impact on the expression of the P53 and the intratumoral microvessel density, but some authors find that only microvessel density is associated with more advanced stage while the expression of P53 does not, larger size tumors are associated with a more advanced disease, in our study the relation was significant with the stage, most patients in category A had stage III disease at presentation [30,31].