The core gene targets possessed higher degree and were more likely to play a key role in EU-RAB anti-osteoarthritis including, Interleukin-6 (IL-6), Vascular endothelial growth factor (VEGFA), Estrogen receptor (ESR1), Epidermal growth factor receptor (EGFR), Mitogen-activated protein kinase 8 (MAPK8) and Caspase3. The gene discussed is VEGFA; the disease is osteoarthritis.