Due to lack of corresponding ligands of a few targets in the PDB, EGFR (PDB id: 1 m17), ESR1 (PDB id: 1r5k), MAPK8 (PDB id: 3pze), GSK3β (PDB id: 1q3d) and IKBKB (PDB id:4kik) were selected based on the core genes, signal pathway and research of osteoarthritis as successfully constructed proteins receptor for molecular docking verification. Here, ESR1 is linked to osteoarthritis.